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Production Operator - Proliant Biologicals

Production Operator - Proliant Biologicals

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Proliant Biologicals, Inc. (PBI) is the world's largest and most experienced manufacturer of animal-derived proteins, producing animal extracts and a variety of grades of "Fraction V" Bovine Serum Albumin (BSA). We are the industry's leading manufacture of BSA and purified animal proteins providing the highest level of consistency, traceability & quality in the market today. We are currently seeking a Production Operator to join our team in Boone, IA to work the weekend night shift.  

Proliant Biologicals, Inc. is an Equal Opportunity Employer.

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PURPOSE: The purpose of this job is to assist in the efficient fractionation of bovine plasma into high purity scientific products for the diagnostic, pharmaceutical and research markets in compliance with FDA, USDA, and OSHA regulations.


Job Duties:

Operate computer-controlled equipment and numerical control devices.

  • Ability to assist in trouble shooting and correction of issues as they are encountered during bioprocessing operations.
  • Ability to assist in simple repair and maintenance operations on bioprocessing equipment.

Assist in the control and monitor centrifuge, filtration system, liquid handling devices, environmental/temperature control systems.

  • Perform necessary lab testing and complete the necessary calculations to adjust the bioprocess equipment.

Follow GMP Standard Operating Procedures for production of product and maintenance of a controlled, aseptic manufacturing environment.

  • Understanding of basic FDA and USDA regulatory requirements as they relate to the processing and testing of the biologicals products.
  • Assist in the updating of necessary documentation to ensure compliance with regulatory requirements in bioprocessing operations.

Assist in the performance of laboratory testing necessary during bioprocessing. This will include:

  • Analysis of protein content by Cobas methodology.
  • Performance of solids testing, by centrifugation and gravimetric methodology.
  • Determination of conductivity.
  • Determination of pH.
  • Test for Non-Volatile Residues (NVRs – Solids/Ash).
  • Perform freeze-thaw testing.
  • Evaluation of clarity.
  • Temperature control operations.
  • Perform calculations necessary to effectively and efficiently produce intermediate and finished products with centrifugation and filtration bioprocesses.

Accurately perform record keeping tasks and perform math and chemistry calculations according to established procedures.


Support Lead Operators and Supervisors in performance of their duties and improvement of bioprocessing operations.

  • Ensure accurate observation and analytical analysis of operations and test results.
  • Assist in the validation of records and evaluation of data that permits the analysis of production efficiencies.
  • Maintain a clean, aseptic manufacturing environment by performing routine cleaning of the manufacturing floor and preventative cleaning/maintenance on equipment.

Fill - Weigh – Sift, package, tie seal and/or palletize containers for customer orders.

  • Ensure that all containers are properly labeled and controlled according to regulatory and corporate guidelines.
  • Maintain the segregation of materials according to their status during in-process and finished product stages of the operation, i.e. accepted, rejected, in-process, quarantined, and released.

Sample and submit product for final analysis by QA using established sanitary methods and procedures.

  • Ability to track samples in testing process.
  • Ability to coordinate activities with QA laboratory to insure timely testing and results generation.

Operate company vehicle and forklift as required.


Job Requirements

• High-school-level knowledge of biology and biochemistry; familiarity/training in bioprocessing.
• Ability to handle materials in accordance with Standard Operating Procedures.
• Ability to learn and work under Bulk Pharmaceutical Chemical Good Manufacturing Practices with established procedures and detailed documentation requirements.
• Ability to learn and safely operate various types of scientific and computerized equipment/machinery required in job duties.
• Ability to interpret and work from oral and written instructions.
• Ability to occasionally operate forklift and/or pallet jacks and to drive a vehicle and maintain valid driver’s license.
• High-school level math and chemistry skills.
• Ability to move freely throughout the bioprocessing area.
• Ability to legibly document data for record-keeping purposes.
• Ability to communicate effectively with Proliant Biologicals personnel.
• Ability to remain calm and professional.
• Ability to read, write, and comprehend instructions related to liquid fractionation, separation, concentration, filtration, centrifugation and other related duties.
• Knowledge of organizational methods and the ability to manage multiple tasks/projects simultaneously.
• Ability to operate all necessary plant and office equipment required to accomplish job duties, such as computers, office telephones including voice mail features, fax machines, etc.
• Ability to work daily, weekends and extended hours as necessary.
• Ability to assist other work related areas, as required.
• Ability to learn and operate windows environment software, such as Microsoft Excel, Microsoft Word, and MAPICS systems.

Job Qualifications


High School Diploma or GED required. 2 or 4 year degree in chemistry or other science preferred.


Experience in biological production or manufacturing preferred.